NOVEL METHODS

摘要

The invention provides methods for screening for compounds that modulate SERCA3 activity, and, in turn, regulate the production of GLP-1, as well as methods of treatment or prophylaxis of metabolic diseases, obesity, diseases and disorders involving abnormal intestinal motility, and other diseases and disorders mediated by GLP-1, and compositions comprising SERCA3 inhibitors. The invention also provides a Serca3 modulator for use as a medicament, a Serca3 modulator for use in the treatment of the aforementioned disease states and, the use of a Serca3 modulator in the manufacture of a medicament for the treatment of the aforementioned disease states.