A HETEROCYCLIC [B]PYRIDONE COMPOUND, INTERMEDIATES THEREOF, METHOD OF PREPARATION AND USES

摘要

?The present invention relates to a heterocyclic [b] pyridone compound of the following formula(I).,and the heterocyclic [b] pyridone compound is used as tyrosine kinase inhibitors, particularly as the c-Met inhibitors. The present invention also relates to the intermediates of the preparation of the heterocyclic [b]pyridone compound as well as the method of preparation. The present invention also relates to the pharmaceutical composition containing such compounds as the active ingredient, and disclose the purpose of heterocyclic [b] pyridone compound as a medicament for the treatment of the disease associated with tyrosine kinase, especially cancer associated with c-Met.