发明名称 |
USE OF GCC LIGANDS |
摘要 |
Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed. |
申请公布号 |
US2012308583(A1) |
申请公布日期 |
2012.12.06 |
申请号 |
US201213526771 |
申请日期 |
2012.06.19 |
申请人 |
WALDMAN SCOTT A.;PITARI GIOVANNI MARIO;PARK JASON;SCHULZ STEPHANIE;WOLFE HENRY;LUBBE WILHELM;THOMAS JEFFERSON UNIVERSITY |
发明人 |
WALDMAN SCOTT A.;PITARI GIOVANNI MARIO;PARK JASON;SCHULZ STEPHANIE;WOLFE HENRY;LUBBE WILHELM |
分类号 |
A61K38/02;A61K;A61K6/00;A61K38/10;A61K38/12;A61K38/17;A61K39/395;A61P35/00 |
主分类号 |
A61K38/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|