发明名称 |
Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions |
摘要 |
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
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申请公布号 |
US8324164(B2) |
申请公布日期 |
2012.12.04 |
申请号 |
US20090649687 |
申请日期 |
2009.12.30 |
申请人 |
DOMINGUEZ HORTA MARIA DEL CARMEN;PADRON PALOMARES GABRIEL RAMON;LOPEZ MARIN NELIA;LORENZO PEREZ NORAILYS;BARBERA BETANCOURT ARIANA;HERNANDEZ GARCIA ARIADNA;MORERA CORDOVA VIVIAN;COSME DIAZ CARELIA;MERINO GARCIA NELSON J.;VAZQUEZ BONACHEA ARIEL;SUAREZ ALBA JOSE;CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
DOMINGUEZ HORTA MARIA DEL CARMEN;PADRON PALOMARES GABRIEL RAMON;LOPEZ MARIN NELIA;LORENZO PEREZ NORAILYS;BARBERA BETANCOURT ARIANA;HERNANDEZ GARCIA ARIADNA;MORERA CORDOVA VIVIAN;COSME DIAZ CARELIA;MERINO GARCIA NELSON J.;VAZQUEZ BONACHEA ARIEL;SUAREZ ALBA JOSE |
分类号 |
A61P19/02;A61K38/17;A61P29/00;C07K14/47 |
主分类号 |
A61P19/02 |
代理机构 |
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