发明名称 |
Compounds, Formulations, and Methods of Protein Kinase C Inhibition |
摘要 |
The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural formulas (I) to (IX). The invention further provides a method of inhibiting or reducing vascular permeability. The method comprising administering to a subject a composition comprising an amount of a compound having a structure selected from the group consisting of structural formulas (I) to (IX) effective to inhibit or reduce vascular permeability. A method of treating or preventing a disease or disorder characterized by abnormal vascular permeability, a method of inhibiting angiogenesis, a method of inhibiting cancer cell proliferation, a formulation, and a method of preparing a formulation also are provided.
|
申请公布号 |
US2012302561(A1) |
申请公布日期 |
2012.11.29 |
申请号 |
US201213458990 |
申请日期 |
2012.04.27 |
申请人 |
ANTONETTI DAVID A.;TITCHENELL PAUL;THE PENN STATE RESEARCH FOUNDATION;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
ANTONETTI DAVID A.;TITCHENELL PAUL |
分类号 |
C12N9/99;A61K31/381;A61K31/4164;A61K31/421;A61K31/4436;A61K31/5377;A61P3/00;A61P29/00;A61P35/00;A61P43/00 |
主分类号 |
C12N9/99 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|