发明名称 |
METHOD AND KIT FOR EVALUATION OF PREDISPOSITION TO DEVELOPMENT OF OBESITY, ANTI-OBESITY AGENT AND METHOD FOR SCREENING THEREOF, NON-HUMAN ANIMAL, ADIPOSE TISSUE, ADIPOCYTE, METHOD FOR PRODUCTION OF TRANSGENIC MOUSE, ANTIGEN, AND ANTIBODY |
摘要 |
<p>It is an object of the present invention to provide a method of evaluating whether or not a subject has a predisposition to obesity or an obesity-related condition or disease, a kit for conducting the method, an anti-obesity drug having an effect of preventing or treating obesity or an obesity-related condition or disease, a method of screening the anti-obesity drug, a non-human animal having a deficiency in the gene associated with obesity, and an adipose tissue or adipocyte of the animal. The method of evaluating a predisposition to obesity of the present invention is a method of evaluating whether or not a subject has a predisposition to obesity or an obesity-related condition or disease. The method includes the step of detecting a copy number variation (CNV) in intron 1 of SLC25A24 gene or a gene polymorphism having a linkage disequilibrium relationship with the CNV in a sample containing a human gene of the subject.If the CNV in intron 1 of the SLC25A24 gene is 0, the subject may be evaluated to have a predisposition to obesity or an obesity-related condition or disease.</p> |
申请公布号 |
EP2415868(A4) |
申请公布日期 |
2012.11.28 |
申请号 |
EP20100774750 |
申请日期 |
2010.05.17 |
申请人 |
THE UNIVERSITY OF TOKYO |
发明人 |
INOUE, SATOSHI;URANO, TOMOHIKO;OUCHI, YASUYOSHI;SHIRAKI, MASATAKA |
分类号 |
C12N15/09;A01K67/027;A61K45/00;A61P3/04;C07K7/08;C07K16/18;C12N5/10;C12Q1/68;G01N33/15;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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