发明名称 |
Perfused three-dimensional cell/tissue disease models |
摘要 |
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a multiwell plate format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects. |
申请公布号 |
US8318479(B2) |
申请公布日期 |
2012.11.27 |
申请号 |
US20050133092 |
申请日期 |
2005.05.19 |
申请人 |
DOMANSKY KAREL;GRIFFITH LINDA G.;TANNENBAUM STEVEN R.;WELLS ALAN;INMAN SAMUEL WALKER;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;UNIVERISTY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
DOMANSKY KAREL;GRIFFITH LINDA G.;TANNENBAUM STEVEN R.;WELLS ALAN;INMAN SAMUEL WALKER |
分类号 |
C12M1/22;B01L3/00;C12M1/00;C12M1/32;C12M1/34;C12M3/00;C12Q1/68 |
主分类号 |
C12M1/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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