| 发明名称 |
Plasmodium liver stage antigens |
| 摘要 |
The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria. |
| 申请公布号 |
US8318183(B2) |
申请公布日期 |
2012.11.27 |
| 申请号 |
US20100722439 |
申请日期 |
2010.03.11 |
| 申请人 |
DUFFY PATRICK;KAPPE STEFAN H. I.;KRZYCH URSZULA;HEPPNER DONALD G.;BERGMAN LAWRENCE W.;MALKOV VLADISLAV A.;TARUN ALICE;WENDLER JASON P.;BACIK IGOR;SEATTLE BIOMEDICAL RESEARCH INSTITUTE;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, ON BEHALF OF THE WALTER REED ARMY INSTITUTE OF RESEARCH;PHILADELPHIA HEALTH & EDUCATION CORPORATION |
发明人 |
DUFFY PATRICK;KAPPE STEFAN H. I.;KRZYCH URSZULA;HEPPNER DONALD G.;BERGMAN LAWRENCE W.;MALKOV VLADISLAV A.;TARUN ALICE;WENDLER JASON P.;BACIK IGOR |
| 分类号 |
A61K39/015;C07H21/04;C12P21/06 |
主分类号 |
A61K39/015 |
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