PROCESS FOR PREPARING PHOSPHATE COMPOUND BEARING ISOTOPE

摘要

A process for easily preparing a phosphate compound bearing an isotope is provided. This process includes an oxidation step of oxidizing a trivalent-phosphorus compound with an oxidizing agent that contains an isotope to synthesize a pentavalent-phosphorus compound into which the isotope has been introduced. The process is preferably applied to the synthesis of nucleic acids such as DNA and RNA. The isotope is preferably a stable isotope. The oxidizing agent is preferably H2 18O, 34S-bearing 3H-1,2-benzodithiol-3-one-1,1-dioxide, or 10B-bearing diisopropylethylamine borane complex.