发明名称 |
Opiate reduction utilizing catalytic hydrogen transfer reaction |
摘要 |
An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method. |
申请公布号 |
US8309727(B2) |
申请公布日期 |
2012.11.13 |
申请号 |
US20080595519 |
申请日期 |
2008.04.15 |
申请人 |
WANG PETER X.;JIANG TAO;CANTRELL GARY L.;BERBERICH DAVID WAYNE;MALLINCKRODT LLC |
发明人 |
WANG PETER X.;JIANG TAO;CANTRELL GARY L.;BERBERICH DAVID WAYNE |
分类号 |
C07D489/08;C07D489/02 |
主分类号 |
C07D489/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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