| 摘要 |
The invention relates to 5-(2-(2-(2-hydroxybenzoyl)hydrazono)ethylthio)-3-phenyl-1H-1,2,4-triazol-1-ium chloride. The compound claimed exhibits expressed neurotropic effect, it is enable to improve survival ability of animals under stroke conditions, to effect on content of adenylic nucleotides, in particular to increase ADP, adenosine triphosphate, adenosine monophosphate level and to reduce CK-BB level, to effect on carbohydrate metabolism indices of brain, in particular to increase pyruvate level and to decrease lactate and malate level, to effect on indices of oxidative modification of protein – APH and KPH, to effect on activity of antioxidant enzymes, in particular to increase activity of SOD, GSH-Px, catalase, and alpha-tocopherol content. |
