发明名称 |
USE OF PROTEIN ARGININE METHYLTRANSFERASES IN REGULATING HEMATOPOIETIC DIFFERENTIATION |
摘要 |
The present invention relates to the manipulations of expression levels or enzymatic activities of PRMTs differentially regulate hematopoietic differentiation toward megakaryocytes or erythrocytes. The modulation of lineage fates of megakaryocyte-erythrocyte progenitors is useful for various purposes, including particular regulation of hematopoiesis for therapy and manufacture of individual blood cells for transplantation. |
申请公布号 |
US2012282237(A1) |
申请公布日期 |
2012.11.08 |
申请号 |
US201113100019 |
申请日期 |
2011.05.03 |
申请人 |
LIN WEY-JINQ;CHANG YUAN-I;HUA WEI-KAI;HUNG YI-CHI;KUAN CHIH-JEN;LEOU JIUN-SHYANG;YAO CHAO-LING;HWANG SHIAW-MIN |
发明人 |
LIN WEY-JINQ;CHANG YUAN-I;HUA WEI-KAI;HUNG YI-CHI;KUAN CHIH-JEN;LEOU JIUN-SHYANG;YAO CHAO-LING;HWANG SHIAW-MIN |
分类号 |
A61K38/45;A61K38/18;A61P7/00;C12N5/078;C12Q1/48 |
主分类号 |
A61K38/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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