发明名称 |
Method for the simultaneous preparation of 3-acetoxy-17-acetamdo-16-formyl-androst-5,16-diene and 3-acetoxy-2'-chloro-5-androsteno[17,6-B]pyridine |
摘要 |
<p>The present invention relates to preparation and biological evaluation of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2′-chloro-5-androsteno[17,16-b]pyridine (5) as gastric proton pump inhibitor and their comparison to that of omeprazole, a clinically employed anti-gastric ulcer drug. Compound (4) exhibited dose dependent inhibition of histamine-stimulated acid secretion in gastric parietal cell with an IC50 value comparable to cimetidine. No mortality or behavioral abnormality of Swiss albino mice was observed under single-dose level of 1 g/Kg body weight of compound (4). Compound (4) further exhibited excellent anti ulcer activity in vivo against indomethacin induced ulcer.</p> |
申请公布号 |
GB2471619(B) |
申请公布日期 |
2012.10.31 |
申请号 |
GB20100018142 |
申请日期 |
2009.03.26 |
申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
ROMESH CHANDRA BORUAH;PANUCHURI GANGADHAR RAO;MOYURIMA BORTHKUR;MADAN GOPAL BARTHAKUR;SUCHANDRA GOSWAMI;PRATAP KUMAR DAS;SUDIP KUMAR KAR;ANNALAXMI CHINNIAH |
分类号 |
C07J75/00;A61K31/568;A61K31/58;A61P1/04;C07J13/00;C07J41/00;C07J71/00 |
主分类号 |
C07J75/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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