The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophenylglycine in activated form (DHPGa) in the presence of an enzyme in an aqueous reaction mixture to form cephradine characterized in that at least step (a) and step (b) of the process are carried out under anaerobic conditions.
申请公布号
EP2513327(A2)
申请公布日期
2012.10.24
申请号
EP20100794956
申请日期
2010.12.14
申请人
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
发明人
MOODY, HAROLD, MONRO;DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA