发明名称 |
Thrombin generation determination method |
摘要 |
A method for measuring a generation of thrombin in a sample of whole blood as a function of time includes adding to a sample of whole blood a fluorogenic substrate and a thrombin activator to form an activated sample. A conversion product is permitted to form in the activated sample. Fluorescence is measured as a function of time from a fluorescent group that is released during the formation of the conversion product with the use of a fluorescence detector. The fluorescence detector operates in an extended range mode and has an increased sensitivity. Thrombin generation as a function of time can then be calculated from the measured fluorescence as a function of time. |
申请公布号 |
US8293493(B2) |
申请公布日期 |
2012.10.23 |
申请号 |
US20100694318 |
申请日期 |
2010.01.27 |
申请人 |
COLL ENRIQUETA;AMIRKOSRAVI ALI;FRANCIS JOHN;ADVENTIST HEALTH SYSTEM/SUNBELT, INC. |
发明人 |
COLL ENRIQUETA;AMIRKOSRAVI ALI;FRANCIS JOHN |
分类号 |
C12Q1/56 |
主分类号 |
C12Q1/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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