发明名称 |
HIGH CONCENTRATION ANTI-TNFalpha ANTIBODY LIQUID FORMULATIONS |
摘要 |
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof. |
申请公布号 |
US2012263731(A1) |
申请公布日期 |
2012.10.18 |
申请号 |
US201113294692 |
申请日期 |
2011.11.11 |
申请人 |
FRAUNHOFER WOLFGANG;REDDEN LAURA;PAULSON SUSAN K.;ZHU TONG;NEU MICHAEL;TSCHOEPE MARKUS;WEBER CARSTEN;GASTENS MARTIN;FEICK ALEXANDER;ABBOTT BIOTECHNOLOGY LTD. |
发明人 |
FRAUNHOFER WOLFGANG;REDDEN LAURA;PAULSON SUSAN K.;ZHU TONG;NEU MICHAEL;TSCHOEPE MARKUS;WEBER CARSTEN;GASTENS MARTIN;FEICK ALEXANDER |
分类号 |
A61K39/395;A61P1/00;A61P1/04;A61P19/02;A61P27/02;A61P29/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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