| 摘要 |
The present application is directed to the field of vector technology, in particular, to vectors useful in gene therapy of retroviral diseases such as HIV. The present invention provides a vector comprising at least two TAR elements, e.g., a retroviral or lentiviral vector, which allows a highly specific expression of a nucleic acid operably linked to the TAR elements in cells comprising TAT, as well as methods of using the same, in particular, a reduced expression in the absence of TAT. |
