Synthetic analogues of abscisic acid with anti-inflammatory and insulin release stimulation effects on human cells

摘要

Compound of formula (I) as drug, having abscisic acid antagonist activity and insulin release stimulating activity, in particular for treatment of inflammatory pathologies of type 2 diabetes.
Compound of formula (I)
wherein R is selected from hydrogen e =O groups, R1 is selected from -H e -OH, R2 is selected from groups having one of following structural formulae (II), (III):
wherein X is selected from -OH, optionally substituted alkylamino-, arylamino-, alkylarylamino- or arylalkylamino-, alkoxy-, aryloxy-, alkylaryloxy- or arylalkoxy- groups, with said groups having from one to eight carbon atoms, with the alkyl chains of such groups being optionally branched, containing unsaturations or forming rings, said groups optionally containing atoms or functionalities different from C, salts of said compound or pharmaceutically acceptable precursors thereof, metabolites, hydrates or solvates thereof, for use as a drug.