发明名称 |
Improved production of secreted proteins by filamentous fungi |
摘要 |
The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype. |
申请公布号 |
EP2511372(A1) |
申请公布日期 |
2012.10.17 |
申请号 |
EP20120175951 |
申请日期 |
2007.10.31 |
申请人 |
DSM IP ASSETS B.V. |
发明人 |
SAGT, CORNELIS, MARIA, JACOBUS;VERRIPS, CORNELIS THEODORUS;MULLER, WALRAVEN HENRY;VAN PEIJ, NOEL NICOLAAS MARIA ELISABETH |
分类号 |
C12N15/80;C07K14/37 |
主分类号 |
C12N15/80 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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