RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS PLASMIDS AND VACCINES

摘要

The present invention relates to novel recombinant plasmids comprising a cassette of at least one, or at least two, or at least three or most preferably at least four foreign genes from Respiratory syncytial virus (RSV) wherein the said genes are inserted at a non-essential site preferably Del III, within the modified vaccinia Ankara (MVA) genome. The invention further relates to a recombinant modified vaccinia Ankara (MVA) virus comprising and capable of simultaneous expression of a cassette comprising of at least one, or at least two, or at least three or most preferably at least four foreign genes from Respiratory syncytial virus (RSV), wherein the said genes are inserted at a non-essential site preferably Del III, within the modified vaccinia Ankara (MVA) genome. The invention further provides compositions and method of treatment using the novel recombinant virus.