| 摘要 |
The disclosure relates to Compounds of Formula (1) and pharmaceutically acceptable salts thereof wherein (a) each of Z1, Z2 and Z3 is independently CH or N; (b) Y is S; (c) Xa and Xb are O; (d) Xc is -CH2-; (e) X2 is -NR1R2, wherein R1 and R2 are each independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl, heteroarylalkyl, or alkylheteroarylalkyl; (f) X4 is hydrogen or halogen; and (g) R is R10-NH-R11 wherein R10 is ethylene or propylene, and R11 is a branched alkyl. Compositions comprising an effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof, and methods to treat or prevent a condition, such as cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof. |
