TRICYCLIC DERIVATIVES OF ?,?'-SUBSTITUTED 3,7-DIAZABICYCLO [3.3.1]NONANES, HAVING A PHARMACOLOGICAL ACTIVITY, AND MEDICAMENTS BASED THEREON

摘要

The present invention relates to new derivatives of ?,?'-substituted 3,7-diazabicyclo [3.3.1] nonanes, having a pharmacological activity, and may be used to treat neurodegenerative pathologies. The present invention also relates to medicaments containing the aforementioned compounds. Tricyclic derivatives of ?,?'-substituted 3,7-diazabicyclo [3.3.1]nonanes, are proposed, which have a pharmacological activity, of the general formula 1 in which : H? here and hereinafter denotes a pharmacologically acceptable acid; X denotes a carbonyl group, methylene group, ??; R1 and R'1 may be identical or different, and each independently of one another denotes ?, C1-C6 alkyl, C1-C10 alkoxy; R2 as a whole is represented by the general formulae (1.1?), (1.2?), (1.3?), (1.4?): medicaments are also proposed for treating cognitive disorders, including attention and memory disorders of various origins for treating behavioral disturbances associated with cognitive disorders; for treating deficit psychiatric disorders with functional psychiatric disturbances; for treating attention deficit hyperactivity disorder (ADHD); for treating hypersomnia and narcolepsy symptoms; for treating mood disorders; for improving memory and attention, and also for assisting training in healthy persons during periods of increased stress; to protect against external influences on the central nervous system in the course of surgical interventions under narcosis or during neurosurgical interventions.