发明名称 |
PROCEDIMIENTO DE IDENTIFICACION DE AGENTES TERAPEUTICOS CONTRA EL MELANOMA Y USO DE AGENTE IDENTIFICADO. |
摘要 |
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer, among those who are able to activate the MDA-5 protein or increase NOXA protein levels and to trigger autophagy. It is based on the fact that activation of dsRNA sensor MDA-5 is able to trigger the destruction of cancer cells by activation both autophagy and apoptosis, autonomously and selectively in tumor cells, without provoking the stabilization of the natural antagonist NOXA, MCL-1. The invention also relates to the use of double-stranded RNAs of the same or similar nature such as polyinosinic-polycytidylic acid (pIC), complexed with carriers such as polyethylenimine polycation (PEI), for the manufacture of medicines for the treatment of cancer. |
申请公布号 |
ES2368963(B1) |
申请公布日期 |
2012.10.10 |
申请号 |
ES20090030417 |
申请日期 |
2009.07.04 |
申请人 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III |
发明人 |
SOENGAS GONZALEZ, MARIA SOLEDAD;TORMO CARULLA, DAMIA |
分类号 |
A61K31/713;A61K47/48;A61K48/00 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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