发明名称 |
Cleavable modifications to reducible poly (amido ethylenimines)s to enhance nucleotide delivery |
摘要 |
Polyplex formulations were prepared using p(TETA/CBA), its PEGylated analog, p(TETA/CBA)-g-PEG2k, and mixtures of the two species at 10/90 and 50/50 wt %, respectively. Increasing PEG wt% inhibited polyplex formation. This work demonstrates the feasibility of preparing homogenous polyplexes by altering the PEG wt% using a mixture of p(TETA/CBA) and p(TETA/CBA)-g-PEG2k products. Further, a single-step method of making p(TETA/CBA)-g-PEG2k is disclosed. |
申请公布号 |
AU2011227264(A1) |
申请公布日期 |
2012.10.04 |
申请号 |
AU20110227264 |
申请日期 |
2011.03.16 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
YOCKMAN, JAMES WILLIAM;BRUMBACH, JONATHAN H.;KIM, SUNG WAN |
分类号 |
C08G65/48;A61K31/7105;C07H21/00;C08L71/00;C12N15/87 |
主分类号 |
C08G65/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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