CONTINUOUS METHOD FOR PRODUCING BIOACTIVE MOLECULE COATED PARTICLES, BIOACTIVE MOLECULE COATED PARTICLES AND USES THEREFOR

摘要

The invention relates to pharmaceutical formulations comprising particles with a substantially non-hygroscopic inner crystalline core and an outer coating comprising at least one bioactive molecule and to methods for forming said particles. An aqueous solution comprising coprecipitant molecules and bioactive molecules is provided. The coprecipitant and the bioactive molecules in solution are admixed with a greater volume of a water miscible organic solvent capable of substantially precipitating the coprecipitant and the bioactive molecules wherein the particles include at least a portion of the bioactive molecules. The particles may then optionally be isolated from the organic solvent.