| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for the use of a gene PIK3CA, that is a member of a gene family of phosphatidylinositol 3-kinases (PI3Ks) which is important regulators of signaling pathways, wherein the majority of mutations clustered near two positions within the PI3K helical or kinase domains, and is one of the most highly mutated oncogenes yet identified in human cancers. <P>SOLUTION: A method is provided for detecting a non-synonymous, intragenic mutation in a PIK3CA coding sequence in a body sample of a human suspected of having a cancer, and assessing that the human is likely to have a cancer if the non-synonymous, intragenic mutation is determined in the body sample. <P>COPYRIGHT: (C)2012,JPO&INPIT |
