发明名称 |
TCR MIMIC ANTIBODIES AS VASCULAR TARGETING TOOLS |
摘要 |
The present invention includes a method of delivering a therapeutic agent into and across an endothelial cell (EC) in a subject in need thereof, comprising: attaching to a T Cell receptor mimic (TCR mimic) an active agent to form a therapeutic agent; and administering to the subject the therapeutic agent in a pharmaceutically acceptable carrier, wherein the therapeutic agent effectively crosses the EC microvascular barrier. Furthermore, the present invention relates to methods of treating diseases (particularly neuronal diseases) or conditions comprising identifying a subject in need of such a treatment and administering to said subject a composition comprising a TCR mimic conjugated to an active agent. |
申请公布号 |
WO2012129520(A1) |
申请公布日期 |
2012.09.27 |
申请号 |
WO2012US30406 |
申请日期 |
2012.03.23 |
申请人 |
TEXAS TECH UNIVERSITY SYSTEM;WEIDANZ, JOHN A.;BICKEL, ULRICH |
发明人 |
WEIDANZ, JOHN A.;BICKEL, ULRICH |
分类号 |
A61K47/48;A61K39/395;A61P25/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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