发明名称 AMINOPYRIDINE DERIVATIVE
摘要 The present invention provides a novel aminopyridine derivative that is excellent in pharmaceutical effects such as a neuroprotective effect, a neurogenesis or nerve regeneration promoting effect, and a cognitive function improving effect and, preferably, is low toxic and delivered at a high rate to the central nervous system. Specifically, the present invention provides a compound represented by the formula (I), wherein ring A represents a monocyclic aromatic hydrocarbon ring or the like; ring B may further have a substituent(s); ring D represents a monocyclic aromatic hydrocarbon ring or the like; L represents a bond, or a methylene group or the like; X represents -NRa- or the like, wherein Ra represents a hydrogen atom or the like; n represents 1 or 2; and R 1 to R 3 each represent a hydrogen atom or the like, wherein ring A and ring D each may be condensed with another ring to form a condensed ring which may have a substituent(s), and ring A-L- in the formula (I) may be bonded to X, provided that when ring A is pyrazole which may be substituted and ring D is benzene which may be substituted, L is a bond; or a salt thereof.
申请公布号 EP2502909(A1) 申请公布日期 2012.09.26
申请号 EP20100831588 申请日期 2010.11.17
申请人 TAKEDA PHARMACEUTICAL COMPANY LIMITED 发明人 TSUKAMOTO TETSUYA;WAKABAYASHI TAKESHI;TOKUNAGA NORIHITO;MIYANOHANA YUHEI
分类号 C07D213/74;A61K31/496;A61K31/5377;A61K31/551;A61P3/10;A61P9/00;A61P9/10;A61P13/00;A61P25/00;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D213/76;C07D401/04;C07D405/04;C07D409/04;C07D413/04 主分类号 C07D213/74
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