| 摘要 |
The present invention relates to an antimicrobial composition for use in delaying the onset of an infection or preventing an infection caused by a microbial organism in an internal cavity of a subject, wherein the antimicrobial composition comprises:
an effective amount of an antimicrobial component comprising
(i) one or more antimicrobial lipid antiseptics comprising one or more fatty acid esters of a polyhydric alcohol, one or more fatty ethers of a polyhydric alcohol, or alkoxylated derivatives of either or both of the ester and ether, or combinations thereof; wherein the antimicrobial composition includes the one or more antimicrobial lipids in a total amount of at least 0.25 wt-%, based on the total weight of the antimicrobial composition; and/or
(ii) iodine and/or an iodophor, wherein the available iodine concentration is at least about 0.05 wt-%, based on the total weight of the antimicrobial composition;
a hydrophilic component; and
a surfactant component distinct from the antimicrobial component;
with the proviso that when the internal cavity comprises a nasal passage, vagina, or oral cavity, the antimicrobial component does not include iodine or chlorhexidine; and
wherein the antimicrobial composition is to be administered in a method comprising the steps of: contacting at least a portion of the interior surface of an opening leading to the internal cavity with an antimicrobial composition; and subsequently at least partially inserting an instrument into the opening. |
