发明名称 |
Plasmonic System for Detecting Binding of Biological Molecules |
摘要 |
Detection and characterization of molecular interactions on membrane surfaces is important to biological and pharmacological research. In one embodiment, silver nanocubes interfaced with glass-supported model membranes form a label-free sensor that measures protein binding to the membrane. The present device and technique utilizes plasmon resonance scattering of nanoparticles, which are chemically coupled to the membrane. In contrast to other plasmonic sensing techniques, this method features simple, solution-based device fabrication and readout. Static and dynamic protein/membrane binding are monitored and quantified.
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申请公布号 |
US2012208174(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
US201113204506 |
申请日期 |
2011.08.05 |
申请人 |
GALUSH WILLIAM J.;SHELBY SARAH A.;MULVIHILL MARTIN J.;TAO ANDREA R.;YANG PEIDONG;GROVES JOHN T.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GALUSH WILLIAM J.;SHELBY SARAH A.;MULVIHILL MARTIN J.;TAO ANDREA R.;YANG PEIDONG;GROVES JOHN T. |
分类号 |
G01N21/75;B82Y15/00;G01N21/47;G01N21/55;G01N21/59 |
主分类号 |
G01N21/75 |
代理机构 |
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地址 |
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