发明名称 |
Small molecules for the modulation of MCL-1 and methods of modulatiing cell death, cell division, cell differentiation and methods of treating disorders |
摘要 |
<p>This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.</p> |
申请公布号 |
AU2011210567(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
AU20110210567 |
申请日期 |
2011.01.31 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
WALENSKY, LOREN D.;STEWART, MICHELLE L.;COHEN, NICOLE |
分类号 |
C07C251/20;A61K31/41;A61P35/00;C07D215/16;C07D249/08 |
主分类号 |
C07C251/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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