THERAPEUTIC AGENT AND PREVENTIVE AGENT FOR DIABETES

摘要

A collagen peptide mixture containing three or more components selected from among Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, the chemically modified products thereof, and the pharmaceutically accepted salts thereof exerts DPPIV inhibitory activity and/or GLP-1 secretion-promoting activity, and thus is effective as a therapeutic agent or a preventive agent for diabetes. At least one peptide selected from among Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro, and Ala-Hyp exerts DPPIV inhibitory activity and/or GLP-1 secretion-promoting activity, and thus is effective as a therapeutic agent or a preventive agent for diabetes. Additionally, the chemically modified product of the aforementioned peptides, or the pharmaceutically accepted salt thereof exert DPPIV inhibitory activity and/or GLP-1 secretion-promoting activity, and thus are effective as a therapeutic agent or a preventive agent for diabetes.