发明名称 |
METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS |
摘要 |
<p>A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims, comprises the step of: a) cyclizing a compound represented by Structural Formula A: under suitable reductive cyclisation conditions to form a compound represented by Structural Formula B: wherein R10 is LG1 or—X1R1, and -LG1 is a suitable leaving group; and b) optionally, when R10 of Structural Formula (B) is LG1, further comprising the step of replacing the -LG1 of Structural Formula (B) with—X1R1 to form the compound represented by Structural Formula (I).</p> |
申请公布号 |
EP2480553(A2) |
申请公布日期 |
2012.08.01 |
申请号 |
EP20100819504 |
申请日期 |
2010.09.24 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER, JEAN-DAMIEN;DURRANT, STEVEN;KAY, DAVID |
分类号 |
C07D487/14 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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