摘要 |
<p>There is provided compounds of formula (I), wherein A1, A2, A3, A4, n, the dotted lines, B1, B1a, B2, B2a, B3, B3a, B4, B4a, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.</p> |
申请人 |
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) |
发明人 |
PASTOR FERNÁNDEZ, JOAQUÍN;MARTÍNEZ GONZÁLEZ, SONIA;ALVAREZ ESCOBAR, ROSA MARÍA;RODRÍGUEZ ARISTEGUI, SONSOLES;GONZÁLES CANTALAPIEDRA, ESTHER;HERNÁNDEZ HIGUERAS, ANA ISABEL;VARELA BUSTO, CARMEN |