发明名称 |
METHODS FOR PROMOTING HEMATOPOIETIC RECONSTITUTION |
摘要 |
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
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申请公布号 |
US2012189592(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
US201213431499 |
申请日期 |
2012.03.27 |
申请人 |
ZON LEONARD I.;NORTH TRISTA E.;GOESSLING WOLFRAM;THE GENERAL HOSPITAL CORPORATION;CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
ZON LEONARD I.;NORTH TRISTA E.;GOESSLING WOLFRAM |
分类号 |
A61K35/14;A61K35/28;A61K35/50;A61P7/00;A61P7/06;A61P35/00;C12N5/0789 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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