发明名称 Cell penetrating peptide conjugates for delivering nucleic acids into cells
摘要 The invention provides cell penetrating peptide-nucleic acid conjugates having the formula P- L-N, wherein P is a cell penetrating peptide, N is a nucleic acid, preferably an oligonucleotide and more preferably a siRNA, and L is a hydrophilic polymer, preferably a polyethylene glycol (PEG)-based linker linking P and N together. Compositions, methods of use and methods for producing such conjugates are also disclosed.
申请公布号 AU2006325030(B2) 申请公布日期 2012.07.26
申请号 AU20060325030 申请日期 2006.12.15
申请人 CELLECTIS 发明人 ALLUIS, BERTRAND;FRUCHART, JEAN-SEBASTIEN
分类号 A61K47/48;A61K31/74;C08G65/329 主分类号 A61K47/48
代理机构 代理人
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