发明名称 |
COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OXYCODONE PRODRUG |
摘要 |
<p>The embodiments provide Compound KC-7, N-1-[(S)-2-(oxycodone-6-enol-carbonyl-methyl-amino)-2-carbonyl-sarcosine-ethyl amine]-arginine-glycine-acetate, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the /compositions comprise a prodrug, Compound KC-7, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.</p> |
申请公布号 |
WO2012096886(A1) |
申请公布日期 |
2012.07.19 |
申请号 |
WO2012US20648 |
申请日期 |
2012.01.09 |
申请人 |
SIGNATURE THERAPEUTICS, INC.;JENKINS, THOMAS, E.;HUSFELD, CRAIG, O. |
发明人 |
JENKINS, THOMAS, E.;HUSFELD, CRAIG, O. |
分类号 |
A01N43/42 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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