发明名称 |
COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OXYCODONE PRODRUG |
摘要 |
The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, Compound KC-8, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug. |
申请公布号 |
WO2012096887(A2) |
申请公布日期 |
2012.07.19 |
申请号 |
WO2012US20649 |
申请日期 |
2012.01.09 |
申请人 |
SIGNATURE THERAPEUTICS, INC.;JENKINS, THOMAS E.;HUSFELD, CRAIG O. |
发明人 |
JENKINS, THOMAS E.;HUSFELD, CRAIG O. |
分类号 |
C07D489/02;A61K31/485;A61P25/04;A61P25/30;C12Q1/37 |
主分类号 |
C07D489/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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