发明名称 |
Dendrimeric compounds comprising amino acids, hyperbranched core compound, process for preparation of dendrimeric compounds comprising amino acids and hyperbranched core compound, and use thereof |
摘要 |
<p>The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene -(CH2)2CONH(CH2)2- group, R2 is an -NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.</p> |
申请公布号 |
AU2009292741(B8) |
申请公布日期 |
2012.07.19 |
申请号 |
AU20090292741 |
申请日期 |
2009.09.18 |
申请人 |
INSTYTUT CHEMII ORGANICZNEJ, POLSKA AKADEMIA NAUK |
发明人 |
LIPKOWSKA, ZOFIA;POLCYN, PIOTR;LIPKOWSKI, ANDRZEJ WOJCIECH |
分类号 |
C07C237/06;A61K31/27;A61K31/4045;A61K31/417;A61K31/4406;A61P31/04;A61P35/00;C07C271/22;C07D209/16;C07D213/75;C07D233/64 |
主分类号 |
C07C237/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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