Monoclonal antibodies against the pbp2-a protein and homologous sequences for the treatment of infections by and immunodiagnostics of bacteria of the firmicutes phylum

摘要

The current invention refers to monoclonal antibodies able to recognize and bind to PBP2a protein and other proteins presenting sequences homologous to PBP2a, including the pathogens methicillin-resistant Staphylococcus aureus - MRSA, coagulase-negative Staphylococcus, Staphylococcus sciuri, Enterococcus spp., and any other bacterium possessing PBP2a or sequences homologous to this protein. The invention still refers to the use of monoclonal antibodies able to recognize and bind to PBP2a protein and other proteins presenting sequences homologous to PBP2a in a complementary immunodiagnosis for detection of resistance to beta-lactams.