发明名称 稳定晶型的奥拉西坦化合物
摘要 本发明属于医药技术领域,具体涉及奥拉西坦化合物,本发明得到的奥拉西坦化合物,含有一个半结晶水,具有的优点:有关物质小,纯度高,稳定性好,即使在高湿度条件下吸湿增重也不明显。
申请公布号 CN102558014A 申请公布日期 2012.07.11
申请号 CN201110351282.6 申请日期 2011.11.09
申请人 天津市汉康医药生物技术有限公司 发明人 严洁;黄欣
分类号 C07D207/273(2006.01)I 主分类号 C07D207/273(2006.01)I
代理机构 代理人
主权项 1. 式Ⅰ所示奥拉西坦化合物,<img file="2011103512826100001DEST_PATH_IMAGE001.GIF" wi="141" he="111" />                          (Ⅰ)所述奥拉西坦化合物,用CuKa射线作为特征X射线粉末测定中,其图谱具有下列2θ衍射角和D值,<tables num="0001"><table><tgroup cols="3"><colspec colname="c001" colwidth="33%" /><colspec colname="c002" colwidth="33%" /><colspec colname="c003" colwidth="33%" /><tbody><row><entry morerows="1">Peak No</entry><entry morerows="1">2Theta</entry><entry morerows="1">d-value</entry></row><row><entry morerows="1">1</entry><entry morerows="1">6.960</entry><entry morerows="1">12.6899</entry></row><row><entry morerows="1">2</entry><entry morerows="1">11.480</entry><entry morerows="1">7.7017</entry></row><row><entry morerows="1">3</entry><entry morerows="1">15.360</entry><entry morerows="1">5.7638</entry></row><row><entry morerows="1">4</entry><entry morerows="1">16.020</entry><entry morerows="1">5.5278</entry></row><row><entry morerows="1">5</entry><entry morerows="1">16.920</entry><entry morerows="1">5.2358</entry></row><row><entry morerows="1">6</entry><entry morerows="1">17.960</entry><entry morerows="1">4.9349</entry></row><row><entry morerows="1">7</entry><entry morerows="1">19.840</entry><entry morerows="1">4.4713</entry></row><row><entry morerows="1">8</entry><entry morerows="1">20.900</entry><entry morerows="1">4.2468</entry></row><row><entry morerows="1">9</entry><entry morerows="1">22.160</entry><entry morerows="1">4.0081</entry></row><row><entry morerows="1">10</entry><entry morerows="1">22.780</entry><entry morerows="1">3.9004</entry></row><row><entry morerows="1">11</entry><entry morerows="1">23.580</entry><entry morerows="1">3.7699</entry></row><row><entry morerows="1">12</entry><entry morerows="1">24.920</entry><entry morerows="1">3.5701</entry></row><row><entry morerows="1">13</entry><entry morerows="1">25.300</entry><entry morerows="1">3.5173</entry></row><row><entry morerows="1">14</entry><entry morerows="1">25.740</entry><entry morerows="1">3.4582</entry></row><row><entry morerows="1">15</entry><entry morerows="1">28.360</entry><entry morerows="1">3.1444</entry></row></tbody></tgroup></table></tables>2θ衍射角的误差为±0.2。
地址 300203 天津市河西区大沽南路敬重里4号3层