MOLECULAR PROBE FOR IMAGING ISLETS OF LANGERHANS, AND USE THEREFORE

摘要

To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides:
Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (1)
Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH 2 (5)
B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (9)
where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring,
where A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R 1 represents a substituent that contains radioactive iodine, R 2 represents either a hydrogen atom or a substituent different from that represented by R 1 , and R 3 represents any one of a bond, a methylene group, and an oxymethylene group.