| 摘要 |
<p>Methods for isolating, characterizing, comparing and using specific components of biological fluids that are characterized on the basis of post-translational modifications of cell surface, and that can be used for the medical management of disorders associated to endothelial dysfunctions. More specifically, said method is for prognosing, diagnosing or monitoring an endothelial dysfunction in a subject, comprising: a) isolating Glyco-EMPs populations in a test sample of biological fluid of said subject by means of an agent binding a specific glycan epitope and at least one further binding agent recognizing a CD antigen from endothelial origin; b) characterizing said test sample Glyco-EMPs populations, and c) comparing said characterized test sample Glyco-EMPs populations with a control sample of Glyco-EMPs populations. Step a) may optionally includes the use of a further binding agent recognizing a phospholipid.</p> |
