发明名称 |
Antibodies With Immune Effector Activity And That Internalize In Folate Receptor Alpha-Positive Cells |
摘要 |
This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (FRA) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to FRA-expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer cells; and methods of treating cancer using the antibodies. |
申请公布号 |
US2012171200(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
US201213356724 |
申请日期 |
2012.01.24 |
申请人 |
NICOLAIDES NICHOLAS C.;GRASSO LUIGI;SASS PHILIP M. |
发明人 |
NICOLAIDES NICHOLAS C.;GRASSO LUIGI;SASS PHILIP M. |
分类号 |
A61K39/395;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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