THE DESIGN OF HYDROLYTICALLY RELEASABLE PRODRUGS FOR SUSTAINED RELEASE NANOPARTICLE FORMULATIONS
摘要
A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
申请公布号
WO2012092339(A2)
申请公布日期
2012.07.05
申请号
WO2011US67531
申请日期
2011.12.28
申请人
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;ALFERIEV, IVAN;CHORNY, MICHAEL;LEVY, ROBERT, J.