发明名称 |
Modified plasminogen activator inhibitor type-1 molecule and methods based thereon |
摘要 |
The present invention relates to a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI-1, but is deficient in one or more functional activities as compared to the wild-type PAI-1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the following functional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions comprising modified PAI-1 molecules and methods of using these pharmaceutical compositions for treatment. |
申请公布号 |
US8211858(B2) |
申请公布日期 |
2012.07.03 |
申请号 |
US20080597686 |
申请日期 |
2008.04.24 |
申请人 |
JANKUN JERZY;SKRZYPCZAK-JANKUN EWA;SELMAN STEVEN H.;THE UNIVERSITY OF TOLEDO |
发明人 |
JANKUN JERZY;SKRZYPCZAK-JANKUN EWA;SELMAN STEVEN H. |
分类号 |
A61K38/00;C07K1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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