发明名称 |
MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR PRODUCING LIPIDS |
摘要 |
This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that overexpress an acyl-acyl carrier protein reductase (acyl-ACP reductase). These microorganisms may optionally overexpress one or more fatty acid synthesis proteins such as ACP and ACCase, and/or one or more polypeptides associated with glycogen breakdown. Also included are photosynthetic microorganisms comprising mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen under reduced nitrogen conditions as compared to a wild type photosynthetic microorganism. The modified photosynthetic microorganisms provided herein are capable of producing increased amounts of lipids such as fatty acids or wax esters and/or synthesizing triglycerides. |
申请公布号 |
WO2012087963(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
WO2011US65896 |
申请日期 |
2011.12.19 |
申请人 |
TARGETED GROWTH, INC.;ROBERTS, JAMES;CROSS, FRED;KAISER, BRETT K. |
发明人 |
ROBERTS, JAMES;CROSS, FRED;KAISER, BRETT K. |
分类号 |
C12N9/02;C12P7/64 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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