摘要 |
Disclosed are novel dapoxetine derivatives and pharmaceutically acceptable salts thereof. The compounds are soluble in water, stable, and easy to process into preparations. In addition, the compounds exhibit improved dissolution rate and taste. Furthermore, the compounds exhibit a small difference in dissolution rate depending on pH. Further disclosed are pharmaceutical compositions including the compounds. The pharmaceutical compositions are useful for the treatment, management or prevention of premature ejaculation. Methods for preparing the dapoxetine derivatives are also disclosed. |
申请人 |
SK CHEMICALS CO., LTD.;OH, JUNG-HOON;RYU, KEUN-HO;KIM, JAE-SUN;KIM, TAE KON;LEE, SOO-MIN;LEE, BONG-YONG;PARK, MINSEOK;HONG, SEOK HYUN;LEE, JUNG A;KIM, HYUK MIN |
发明人 |
OH, JUNG-HOON;RYU, KEUN-HO;KIM, JAE-SUN;KIM, TAE KON;LEE, SOO-MIN;LEE, BONG-YONG;PARK, MINSEOK;HONG, SEOK HYUN;LEE, JUNG A;KIM, HYUK MIN |