发明名称 |
Ovr115 antibody compositions and methods of use |
摘要 |
The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr115) antibodies that bind to Ovr115 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Ovr115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr115 antibodies. The invention encompasses a method of producing the anti-Ovr115 antibodies. Other aspects of the invention are a method of killing an Ovr115-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr115 antibody and a method of alleviating or treating an Ovr115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr115 antibody to the mammal. |
申请公布号 |
US8207311(B2) |
申请公布日期 |
2012.06.26 |
申请号 |
US20040556478 |
申请日期 |
2004.05.17 |
申请人 |
PILKINGTON GLENN;KELLER GILBERT-ANDRE;LI WENLU;CORRAL LAURA;SIMON IRIS;DIADEXUS, INC. |
发明人 |
PILKINGTON GLENN;KELLER GILBERT-ANDRE;LI WENLU;CORRAL LAURA;SIMON IRIS |
分类号 |
C07K16/00;A61K39/00;A61K39/395;C07K16/30;C07K17/00;C07K17/14;C12N5/07;C12N5/16;C12P21/08;G01N33/53;G01N33/574 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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