The invention provides a nucleic acid sequence encoding a chimeric adenovirus hexon protein, wherein the chimeric hexon protein comprises a first portion and a second portion. The first portion comprises at least 10 contiguous amino acid residues from a first adenovirus serotype (e.g., serotype 5 adenovirus hexon protein), optionally with one amino acid substitution. The second portion comprises (a) at least one hypervariable region (HVR) of a hexon protein of an adenovirus of a second adenovirus serotype, or (b) at least one synthetic hypervariable region (HVR) that is not present in the hexon protein of the wild-type adenovirus of the first adenovirus serotype.
申请公布号
WO2012083297(A2)
申请公布日期
2012.06.21
申请号
WO2011US65753
申请日期
2011.12.19
申请人
GENVEC, INC.;BRUDER, JOSEPH, T.;BROUGH, DOUGLAS, E.